There are several different options for both Juventus and Milan going into tonight’s game, with fitness concerns on one side and tactical changes on the other.
It kicks off in Turin at 19.45 GMT, click here for a match preview.
The Bianconeri need a victory to recapture the top spot after Inter beat Verona 2-1 on Saturday.
Giorgio Chiellini is the only absentee now, along with birthday boy third choice goalkeeper Mattia Perin, but there are some doubts.
Maurizio Sarri said he wants late fitness tests on both Matthijs de Ligt – who missed the midweek 2-1 win at Lokomotiv Moscow with a sprained ankle – and Cristiano Ronaldo.
CR7 was substituted in that Champions League match because he has a slight knee issue, which is in turn leading him to adjust his posture to overcompensate, putting extra pressure on the thigh muscles.
It’s very unlikely Sarri will rest Ronaldo for this game, so ex-Milan striker Gonzalo Higuain is the favourite to be his partner rather than Paulo Dybala.
Federico Bernardeschi should return in the trequartista role, picked ahead of Douglas Costa, with Aaron Ramsey either in a midfield spot or on the bench.
Milan are without Mateo Musacchio, Samu Castillejo and Fabio Borini, while Franck Kessie was left at home despite not being injured, as his attitude and general fitness levels have not impressed coach Stefano Pioli.
Although he did test out a 3-4-2-1 formation in training, it’s widely reported Pioli will stick with the 4-3-3 shape in Turin, a stadium where Milan have lost their last eight visits.
Andrea Conti is tipped for right-back rather than Davide Calabria, as Leo Duarte takes over in the centre of defence.
Ismael Bennacer and Rade Krunic should again form the midfield with either Lucas Paqueta or Lucas Biglia.
Suso returns from his hip injury to complete the trident with Hakan Calhanoglu and Krzysztof Piatek, as Rafael Leao and Ante Rebic have not shown the right attitude when coming off the bench in recent outings.
Juventus: Szczesny; Cuadrado, Bonucci, De Ligt, Alex Sandro; Bentancur, Pjanic, Matuidi; Bernardeschi; Higuain, Cristiano Ronaldo
Milan: G Donnarumma; Conti, Duarte, Romagnoli, Theo Hernandez; Paqueta, Bennacer, Krunic; Suso, Piatek, Calhanoglu
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