Paulo Dybala is in doubt with a stomach bug and Merih Demiral is the favourite to start in the Juventus defence against Lokomotiv Moscow.
It kicks off at 17.55 GMT and a win would put the Bianconeri into the Champions League Round of 16.
Juan Cuadrado is suspended, so makes way for Danilo, while Matthijs de Ligt joined Giorgio Chiellini on the treatment table with a sprained ankle.
Turkey international Demiral is the favourite to start in his place, ahead of Daniele Rugani, even though it would be the ex-Sassuolo defender’s career debut in the Champions League.
Dybala is struggling with a stomach bug, so Gonzalo Higuain is expected to partner Cristiano Ronaldo upfront, with Aaron Ramsey facing competition from both Federico Bernardeschi and Douglas Costa for the trequartista role.
Douglas Costa played there for Shakhtar Donetsk, but he too is not 100 per cent fit after a long injury lay-off.
Lokomotiv Moscow had been leading 1-0 in Turin until a late Dybala brace secured Juve’s victory, so will be confident of causing an upset on their home turf.
The injury crisis remains intensive, missing Luka Djordjevic, Anton Miranchuk, Fedor Smolov, Jefferson Farfan and Boris Rotenberg.
Compared to the last meeting, Rufat Zhemaletdinov and Maciej Rybus are available again.
Eder is again the only real candidate to start upfront with support from ex-Inter creative midfielder Joao Mario.
Lokomotiv Moscow: Guilherme; Ignatyev, Höwedes, Murilo, Corluka, Rybus; Krychowiak, Barinov, Joao Mario; Al Miranchuk, Eder
Juventus: Szczesny; Danilo, Bonucci, Demiral, Alex Sandro; Khedira, Pjanic, Bentancur; Ramsey; Higuain, Ronaldo
Ref: Buquet (FRA)
Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/